Ghana recorded a 1-0 win over the Cranes of Uganda at the Stade de Port Gentil on Tuesday evening.
The four time champions broke the deadlock after Asamoah Gyan was fouled in the 18-yard box in the 30 minute of the game.
West Ham United's winger Andre Ayew struck the ball firmly from the spot to grab Ghana first victory in the tournament.
The Cranes failed to equalise the goal when their numerous chances were saved by Razak Braimah.
Egypt will face Mali in the second game of the Group D this evening.
