Ghana were beaten 2-1 by their West African counterparts in the quarters of the tournament at the Indira Gandhi Athletic Stadium.
The Malians started the game on a good note as they managed to finish the first department of the game in a 1-0 lead.
17-year-old Hadji Drame grabbed the opener for the Eaglets of Mali in the 15th minute of the game.
Coach Paa Kwesi Fabian's side mounted pressure on the reigning Africa Champions but failed to materialised their chances as the first half ended in a 1-0 win for Mali.
Back from the break, the Mali U17 team continued swinging their brilliant passes as they managed to double the lead on the hour mark.
Djemoussa Traore doubled the lead for Eaglets after a blunder committed by goalkeeper Ibrahim Danlad in the 61st minute of the game.
The Black Starlets pulled one back through young enforcer Kudus Mohammed who neatly converted a spot-kick awarded to them in the 70th minute.
Ghana failed to utilize their set-pieces awarded to them as the match ended in a 2-1 victory in favor of Mali.